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Paxil (paroxetine) is an antidepressant used to treat depression, panic disorder, and anxiety disorders. Learn about Paxil's side effects, interactions, and more. Paroxetine, sold under the brand name Paxil among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [5] used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and … Paroxetine (Paxil, Brisdelle) is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD). Paxil (paroxetine) is a commonly prescribed medication that's FDA approved to treat depression, anxiety, and other conditions. Without insurance, a 30-day supply of brand-name Paxil at a 20 mg dose can cost $ 307.50. 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