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Find today's lowest Xifaxan price. Compare coupons, discount cards, savings programs and pharmacy costs side by side, with or without insurance. Xifaxan (rifaximin) is a prescription antibiotic used to treat irritable bowel syndrome with diarrhea (IBS-D), traveler's diarrhea caused by certain strains of E. coli, and to reduce the risk of recurrent hepatic encephalopathy in adults with liver disease. Xifaxan is prescribed to treat certain types of diarrhea and to lower the risk of a brain condition in adults with severe liver disease. It's a brand-name drug, available as the generic medication rifaximin. It comes as an oral tablet. The cost with or without insurance can depend on several factors. It might be lowered by using a coupon. Reduce Xifaxan costs to $80/month with the Patient Assistance Program. Reliable support for digestive and infection-related conditions. 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